In this essay, we argue that there exist obvious parallels between questions that inform philosophy of chemistry and the so-called hard problem of consciousness in philosophy of mind. These include questions regarding the emergence of higher-level phenomena from lower-level physical states, the reduction of higher-level phenomena to lower-level physical states, and 'downward causation'. We, therefore, propose that the 'hard problem' of consciousness should be approached in a manner similar to that used to address parallel problems in philosophy of chemistry. Thus, (...) our contribution begins by scrutinizing the ways chemists and quantum chemists think about and use different levels of organization and chemical relations and relata and then investigates the problem of 'downward causation' as it relates to the question of emergence. We demonstrate that the science of the transformation of 'substances', namely chemistry, enables us to go beyond substantialism and to develop, instead, a non-substantialist account of levels of reality. Similarly, the 'hard problem' of consciousness will require that we transcend traditional emergentism and its substantialist conception of mind. As with chemical phenomena, mental phenomena must be examined in terms of the relationality of wholes and parts, and this will require the development of a mereology that explains how parts and wholes may co-define each other. Like the non-classical and non-transitive mereology that has been proposed for quantum chemistry, an extended mereology for philosophy of mind must be one that entangles the whole, its parts, and the environment, thus rendering 'downward causation' into a relational concept. This proposal is neither a reductionist analysis that only needs the parts to define the whole, nor a merely holistic description within which the whole is necessary to define the parts. Rather, we propose that the parts, the whole, and the environment co-define each other so that our understanding of parts, wholes, and environment as independent concepts must itself be altered. (shrink)

This chapter first evokes the objects of chemistry and the role played by experimentation in the constitution of its objects. It then studies how chemists set up experimental protocols to deal with the dependence of chemical bodies on the inert or living environments in which they are found. To this end, its pays particular attention to the preparation of reference matrices for measurement and for the validation of results. In so doing, it stresses the fact that chemists use a dizzying (...) pluralism of instruments, procedures, reasonings, and methods in order to characterize and quantify substances, which are never truly detachable, except in the case of approximations satisfying particular objectives, from the empirical complex {apparatus-methods-chemical substances-associated medium} in which they are scrutinized. (shrink)

This paper aims to connect philosophy of chemistry, green chemistry, and moral philosophy. We first characterize chemistry by underlining how chemists: co-define chemical bodies, operations, and transformations; always refer to active and context-sensitive bodies to explain the reactions under study; and develop strategies that require and intertwine with a molecular whole, its parts, and the surroundings at the same time within an explanation. We will then point out how green chemists are transforming their current activities in order to act upon (...) the world without jeopardizing life. This part will allow us to highlight that green chemistry follows the three aforementioned characteristics while including the world as a partner, as well as biodegradability and sustainability concerns, into chemical practices. In the third part of this paper, we will show how moral philosophy can help green chemists: identify the consequentialist assumptions that ground their reasoning; and widen the scope of their ethical considerations by integrating the notion of care and that of vulnerability into their arguments. In the fourth part of the paper, we will emphasize how, in return, this investigation could help philosophers querying consequentialism as soon as the consequences of chemical activities over the world are taken into account. Furthermore, we will point out how the philosophy of chemistry provides philosophers with new arguments concerning the key debate about the ‘intrinsic value’ of life, ecosystems and the Earth, in environmental ethics. To conclude, we will highlight how mesology, that is to say the study of ‘milieux’, and the concept of ‘ecumeme’ proposed by the philosopher and geographer Augustin Berque, could become important both for green chemists and moral philosophers in order to investigate our relationships with the Earth. (shrink)

This paper first queries what type of concept of emergence, if any, could be connected with the different chemical activities subsumed under the label ‘quantum chemistry’. In line with Roald Hoffmann, we propose a ‘rotation to research laboratory’ in order to point out how practitioners hold a molecular whole, its parts, and the surroundings together within their various methods when exploring chemical transformation. We then identify some requisite contents that a concept of emergence must incorporate in order to be coherent (...) from the standpoint of the scientific practices involved. In this respect, we finally propose a relational form of emergence which pays attention to the constitutive role of the modes of intervention and to the co-definition of the levels of organization. No metaphysical distinction between the higher and basic levels of organization is supposed, but only a plurality of modes of access. Moreover, these modes of access are not construed as mere ways of revealing intrinsic patterns of organization but, on the contrary, are considered to be active elements on which the constitution of those patterns depends. What is at stake in this paper is therefore not an ontological form of emergence but an agnostic one which fits what chemists do in their daily work. (shrink)

How do chemists assign numbers to chemicals properties? What do these numbers refer to? To answer these questions, we will first point out both the context-dependence of chemicals and the epistemic limitations of chemistry. We will then investigate how chemists use various procedures to stabilize measurements and how they use mixtures of samples as “references” in order to determine the amount of different chemicals in a sample. This study will enable us to query how it is possible for chemists to (...) change one factor while holding others constant at each step of the measurement procedure. This part of our work which will lead us to query the meaning of the ceteris paribus clause and the very possibility of making holistic inferences in the domain of chemistry. To conclude, we will highlight how methodological pluralism developed by chemists makes it possible for a relational type of consistency to emerge. (shrink)

Chemists do not aim at testing preconceptions or theoretical hypotheses only; they first and foremost produce and determine the object of chemical investigation: they learn through making. They never cease to create and stabilize heterogeneous devices, methods, models, and theories in order to act upon the world. Chemical bodies cannot be studied in isolation; their properties constitutively depend on what surrounds and acts upon them. Starting from the specificity of chemical practices, this paper investigates the meaning of consistency, inconsistency, and (...) that of the ceteris paribus clause, in this domain of science. In so doing, it defends the idea that studying what we call ‘a lack of consistency’ should always include the scrutiny of: the way a particular scientific practice is stabilized, and the ontological or pragmatic assumptions about the entities and processes upon which this practice revolves. (shrink)

This paper explores how chemists are transforming their own current background in order to act upon the world without jeopardizing life. In this respect, I will envisage science as both a system of propositions and a set of engaged practices. The scrutiny of chemical innovations will allow me to query the concepts of paradigm and that of scientific community . In doing so, I will connect the philosophy of science with the philosophy of technology so as to think about our (...) relation with the world. (shrink)

Philosophers mainly refer to quantum chemistry in order to address questions about the reducibility or autonomy of chemistry relative to quantum physics, and to argue for or against ontological emergence. To make their point, they scrutinize quantum approximations and formalisms as if they were independent of the questions at stake. This paper proposes a return to history and to the laboratory so as to emphasize how quantum chemists never cease to negotiate the relationships between a molecule, its parts, and its (...) environment. This investigation will enable us to draw methodological conclusions about the role of history within philosophical studies, and to examine how quantum chemistry can clarify important philosophical and mereological issues related to the emergence/reduction debate, or to the way instruments and contexts are involved in the material making and the formal description of wholes and parts. (shrink)

This paper aims to highlight how the philosophy of chemistry could be of help for rethinking Nature today. To do so, we will point out: the co-definition of chemical relations and chemical relata within chemical activities; the constitutive role of the modes of intervention in the definition, always open and provisional, of “active” chemical bodies; and the mutual dependence of the levels of organization in chemistry. We will insist on the way chemists tailor networks of interdependencies within which chemical bodies (...) and properties are context-sensitive and mutually determined by means of particular chemical operations or transformations. To conclude, we will show how the specific action of bodies upon the Earth at different scales of space and time, and how the relational definition of a chemical body, pave the way for a new understanding of Nature. (shrink)

In line with their previous studies dedicated to quantum chemistry (Gavroglu and Simões 1994, 2000; Simões and Gavroglu 1997, 2001), the last joint publication by Kostas Gavroglu and Ana Simões provides the readers not only with a fine-grained, rigorous, and highly valuable book on the history of science but also with stimulating epistemological insights about the way ‘in-between’ disciplines, to use the authors’ turn of phrase, emerge from the convergence of diverging ‘styles’ of research and heterogeneous practices. To make their (...) point, the authors divide their work into four main chapters before drawing epistemological and historiographical conclusions in the fifth and last part of their work. The first chapter entitled ‘Quantum Chemistry qua Physics: The Promises and Deadlocks of Using First Principles’ focuses mainly on German researchers’ contributions in the development of quantum chemistry. In this respect, it highlights four pioneering moments: (1) Walter Heitler and Fritz Lo. (shrink)

This volume connects chemistry and philosophy in order to face questions raised by chemistry in our present world. The idea is first to develop a kind of philosophy of chemistry which is deeply rooted in the exploration of chemical activities. We thus work in close contact with chemists. Following this line of reasoning, the first part of the book encourages current chemists to describe their workaday practices while insisting on the importance of attending to methodological, metrological, philosophical, and epistemological questions (...) related to their activities. It deals with sustainable chemistry, chemical metrology, nanochemistry, and biochemistry, among other crucial topics. In doing so, those chemists invite historians and philosophers to provide ideas for future developments. In a nutshell, this part is a call for forthcoming collaborations focused on instruments and methods, that is on ways of doing chemistry. The second part of the book illustrates the multifarious ways to study chemistry and even proposes new approaches to doing so. Each approach is interesting and incomplete but the emergent whole is richer than any of its components. Analytical work needs socio-historical expertise as well as many other approaches in order to keep on investigating chemistry to greater and greater depth. This heterogeneity provides a wide set of methodological perspectives not only about current chemical practices but also about the ways to explore them philosophically. Each approach is a resource to study chemistry and to reflect upon what doing philosophy of science can mean. In the last part of the volume, philosophers and chemists propose new concepts or reshape older ones in order to think about chemistry. The act of conceptualization itself is queried as well as the relationships between concepts and chemical activities. Prefaced by Nobel Laureate in Chemistry, Roald Hoffmann, and by the President of the International Society for the Philosophy of Chemistry, Rom Harrè, this volume is a plea for the emergence of a collective cleverness and aims to foster inventiveness. (shrink)

In recent publications, Harré and Llored Challenges of cultural psychology, Routledge, London, pp 189–206, 2018a; Philosophy, 93:167–186, 2018b; The analysis of practices, Cambridge Scholars Publishing, Newcastle upon Tyne, 2019) take the role of philosophy of science as a digging out of the ‘hinges’, that are the tacit elements of a discipline. In this perspective, the philosophy of chemistry consists, at least partly, in making explicit the hinges on which chemistry turns and in examining their origins and logical status. In (...) this paper, we propose to query Harré and Llored’s research approach in the case study of the element chlorine. Whereas most early nineteenth-century textbooks define the element as the endpoint of chemical decomposition, the controversy surrounding the element chlorine reveals implicit criteria that surpass operational indivisibility. From 1810 onwards, Davy argued that chlorine was a simple substance; yet, even though it had been known to be indecomposable using the strongest instruments available, the widespread acceptance of chlorine took until 1816–1818. The main factor that contributed to the resolution of the debate was the discovery of iodine, an analogous element which provided new theoretical coherence between explanations of different phenomena :247–258, 1959). Thus, the idea that elements should qualitatively resemble each other is an implicit belief which appears to have been shared by many prominent chemists of the time, despite the fact that it was not stated as part of the definition of the chemical element. Could we assert that this idea was a ‘hinge’ around which the notion of chemical element revolved? Our talk will answer this question. (shrink)

Mereology is the logic of part—whole concepts as they are used in many different contexts. The old chemical metaphysics of atoms and molecules seems to fit classical mereology very well. However, when functional attributes are added to part specifications and quantum mechanical considerations are also added, the rules of classical mereology are breached in chemical discourses. A set theoretical alternative mereology is also found wanting. Molecular orbital theory requires a metaphysics of affordances that also stands outside classical mereology.

This paper widens the scope of our previous paper (Harré and Llored in Found Chem 13:63–76, 2011) by scrutinizing how whole/parts relations are involved in the study of molecules. In doing so, we point out two mereological fallacies which endanger both philosophical and chemical inferences. We also further explore how the concept of affordance is related to our mereological investigation. We then refer to quantum chemistry in order to pave the way for a new mereological approach for chemistry.

Mulliken proposed an Aufbauprinzip for the molecules on the basis of molecular spectroscopy while establishing, point by point, his concept of molecular orbit. It is the concept of electronic state which becomes the lever for his attribution of electronic configurations to a molecule. In 1932, the concept of orbit was transmuted into that of the molecular orbital to integrate the probabilistic approach of Born and to achieve quantitative accuracy. On the basis of the quantum works of Hund, Wigner, Lennard-Jones and (...) group theory, he suggested the fragment method to establish the characteristics of molecular orbital for polyatomic molecules. These developments make it possible to bring elements of thought on the relation between a molecular whole and its parts . An operational realism combined with the second law of thermodynamics can pave the way for interesting tracks in the mereological study of chemical systems. (shrink)

WHO II low grade glioma evolves inevitably to anaplastic transformation. Magnetic resonance imaging is a good non-invasive way to watch it, by hemodynamic and metabolic modifications, thanks to multinuclear spectroscopy 1H/31P. In this work we study a multi-scale minimal model of hemodynamics and metabolism applied to the study of gliomas. This mathematical analysis leads us to a fast-slow system. The control of the position of the stationary point brings to the concept of domain of viability. Starting from this system, the (...) equations bring to light the parameters that push glioma cells out of their domain of viability. Four fundamental factors are highlighted. The first two are cerebral blood flow and the rate of lactate transport through monocarboxylate transporters, which must be reduced in order to push glioma out of its domain of viability. Another factor is the intra arterial lactate, which must be increased. The last factor is pH, indeed a decrease of intra cellular pH could interfere with glioma growth. These reflections suggest that these four parameters could lead to new therapeutic strategies for the management of low grade gliomas. (shrink)

One of the key features of modern mathematics is the adoption of the abstract method. Our goal in this paper is to propose an explication of that method that is rooted in the history of the subject.

Le pédagogue Antoine de La Garanderie (1920-2010) laisse un héritage intellectuel particulièrement riche et stimulant. Le rayonnement de sa pensée au cours des trois dernières décennies, tant en France qu'à l'étranger, et son influence sur les pratiques pédagogiques, formatives, voire thérapeutiques, font de lui l'une des figures marquantes de notre culture contemporaine. Cet ouvrage explore trois grands champs de réflexion et de recherche : le premier concerne la validité et la pertinence, au plan épistémologique, des recherches qu'il a conduites, désignées (...) sous le terme générique de " Gestion mentale ", et en référence à d'autres courants de pensée ; le second aborde l'orientation générale des expérimentations pédagogiques ou didactiques auxquelles ces recherches ont donné lieu et dont il convient d'évaluer la portée et la valeur, tant heuristiques que praxéologiques ; le troisième relève des fondements proprement anthropologiques où s'enracinent ses concepts et ses propositions et qu'il importe autant de dévoiler que de situer : sa foi en l'éducabilité, sa conception de l'évolution et du progrès. (shrink)

In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these...

Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our ...

La représentation et l'expression sont communément tenues pour caractéristiques des œuvres d'art. Les questions que soulèvent ces notions ont jalonné le développement de l'esthétique et durablement marqué les discussions autour desquelles un grand nombre de théories ont vu le jour en philosophie de l'art. Ce livre tente de les analyser en se frayant un chemin dans les difficultés qui leur sont liées, au carrefour des traditions et des courants qui s'en disputent aujourd'hui l'héritage.

There is no science that does not rest on a metaphysics, though typically it remains concealed. It is the responsibility of the philosopher to uncover this metaphysics, and then to subject it to criticism. What I have tried to show is that cybernetics, far from being the apotheosis of Cartesian humanism, as Heidegger supposed, actually represented a crucial moment in its demystification, and indeed in its deconstruction.

v. 1. A défaut-- la littérature -- v. 2. Arts et philosophie mêlés.

Aborde de nombreux thèmes, notamment : la vérité en mathématiques, la construction du vrai dans le développement cognitif de l'enfant, la procédure de Ramsey et le problème du réalisme scientifique, les relations de l'astrophysique et de la cosmologie avec l'observation.

Les fondements de la théorie du choix rationnel, dans ses multiples déclinaisons (économie théorique, théorie de la décision, théorie des jeux, théorie de l'action que l'on trouve au cœur de la philosophie analytique, etc.), ne sont plus aussi assurés en cette fin du XXe siècle qu'ils semblaient l'être durant, ou immédiatement après, la Seconde Guerre mondiale, lorsqu'un John von Neumann ou un Leonard Savage en posaient les prolégomènes. A la source des difficultés présentes, on trouve l'ambition croissante de la théorie (...) du choix rationnel d'expliquer, et surtout de fonder, des phénomènes très éloignés du champ à l'intérieur duquel elle s'était d'abord confinée. Le défi le plus grand que le choix rationnel s'est fixé à lui-même est de rendre compte de la possibilité du jugement moral dans un monde d'individus isolés, autonomes et intéressés (et notamment de la promesse, de l'engagement, du contrat, de la parole donnée et tenue, de la menace, de la dissuasion crédible et efficace). C'est en tentant de relever ces défis que les théoriciens ont rencontré sur leur chemin, comme autant d'obstacles inattendus, des paradoxes redoutables. Ce livre présente les recherches les plus récentes dans le domaine. Il s'en dégage la thèse que le paradigme de la rationalité est radicalement incomplet. L'idéal de transparence qui est au cœur de la théorie du choix rationnel est incapable de venir à bout de l'extériorité et de l'opacité du collectif. Si elles ne prenaient appui sur des références extérieures qui les guident en les " poussant ", les interactions entre acteurs rationnels seraient en général incapables de produire à elles seules quoi que ce soit de déterminé. Les recherches ici présentées s'attachent à définir ce que sont ces dispositifs collectifs cognitifs qui encadrent et servent de support aux décisions individuelles. Elles s'inscrivent dans cette synergie entre sciences sociales, sciences cognitives et philosophie qui renouvelle aujourd'hui les sciences de l'homme. (shrink)